Twenty years is a very long time — for a relationship or a TV collection like Grey’s Anatomy. Just if you suppose there’s nothing extra to do, shock!
Fans proceed to tune into Grey’s each season for the most recent medical instances, relationship drama, and strong storytelling.
We do not get as a lot Meredith lately, however there’s nonetheless sufficient to fulfill viewers, together with the connection mishaps along with her new love curiosity.
While the present does not have the identical pizzazz and character compatibility because it did within the early years, there’s loads of relationship messiness to entice followers.
But regardless of how nice — or dangerous — issues get at GSM, some relationships have occurred within the final 20 years that followers will always remember. And some by no means obtained the ending they deserve.
Here is a listing of our favourite on-screen Grey’s Anatomy ‘ships of all time.
Meredith Grey and Derek Shepherd
The chemistry between Meredith Grey and Derek Shepherd hooked viewers from the primary glimpse and nonetheless captivates twenty years later.
A love like theirs by no means dies, even when one (Derek) does. Their relationship went by way of the worst of ups and downs, like assembly Derek’s spouse (ex).
No different couple has captured that air of eternal love, of being there for one another it doesn’t matter what.
Derek will not be with Meredith in individual anymore, however we will nonetheless really feel their love years after Derek’s soul left this mortal airplane.
Meredith Grey and Nick Marsh
Fans cherished the union between Nick and Meredith from the beginning. Meredith was lastly opening her coronary heart once more years after Derek’s dying.
What began as long-distance turned a severe ‘ship when Nick joined the workers at Grey Sloan. While Meredith left GSM for a job in Minnesota.
In Season 20, followers adore seeing Nick taking part in the attentive mum or dad to the youngsters again in Minnesota whereas Mer is again in Seattle at GSM.
Seriously, can they ever be in the identical place concurrently?
Derek Shepherd and Addison Montgomery Shepherd
We cannot point out Derek’s former relationship with out together with them on this listing. Because the 2 medical doctors made an unimaginable pairing to start with.
Before Addison had an affair with Derek’s finest pal Mark. It’s her infidelity that pushed Derek to Grey Sloan (Seattle Grace Hospital) and into the arms of Meredith.
While Derek and Addison had been nonetheless married on the time, it was in title solely.
Viewers had a break up response on whether or not Derek ought to have labored more durable to maintain his marriage with Addison going or finish the ‘ship to deal with what was growing between him and Meredith.
Once a cheater and all that. The Mer-team gained as Derek lastly selected a path.
Addison Montgomery and Mark Sloan
We fell in love with the horny womanizer Mark Sloan from our first assembly, regardless of being a scoundrel for his affair with Addison.
We had much less constructive emotions for Addison, the dishonest spouse.
Despite their relationship beginning by way of infidelity, we instantly rooted for them.
If Addie was with Mark, Derek was free to pursue Meredith.
It did not take lengthy to study that Mark wasn’t simply Dr. McSteamy, an attractive face and hard-toned physique. He was additionally a superb, gifted physician and a pleasant man with sturdy relationship potentialities.
We virtually felt sorry for his love-sick emotions. He gave up his life within the metropolis to observe Addi to Seattle.
Despite his sacrifices, their relationship withered into nothingness. However, everybody stayed good buddies, so there was mild on the finish of the tunnel.
Mark Sloan and Callie Torres
Mark’s persona made him an ideal candidate to be buddies with females like Addison and Callie Torres.
He and Callie began off as a random hookup.
And they continued to have a sexual association with out the messy feelings of a relationship. Many followers hoped they’d turn out to be extra.
Alas, friendship is all that was there, regardless of having a daughter collectively in later seasons. Their friendship helped Callie understand her bisexuality, getting her on observe to fulfill the 2 nice loves of her life — each females.
Mark Sloan and Lexie Grey
Poor Mark went by way of the wringer when it comes to relationships. It appeared like he could not catch a break on discovering the correct lady.
First Addison, then Callie.
Things appeared to vary when he met the candy and younger Lexie Grey. Sparks flew, as did the tensions and warnings. Their union was forbidden, which made it all of the extra thrilling.
We noticed a distinct facet to Mark, however his need for a secret relationship wasn’t truthful to Lexi, even when it was for good causes — like conserving his finest pal from discovering out he was sleeping together with his sister-in-law.
While the eagerness was there, the inspiration wasn’t. Mark wished youngsters. Lexie did not.
Despite splitting up, they stayed in love proper up till their deaths after the airplane crash in Season 8 Episode 24.
Callie Torres and George O’Malley
George was a nerdy physician, so nobody was extra shocked than him when the new Callie confirmed curiosity. But she was, as had been we.
But whereas Callie gave the impression to be all in, George was extra reluctant to commit. He proposed on a whim, and they obtained married in Vegas.
But the wedding was a brief one. Callie left George after discovering out about his one-night stand and true emotions for Izzie.
His dying hit Callie exhausting, leading to her going again to Sloan, paving the best way for her to have Mark’s child and uncover her twin sexuality.
George O’Malley and Izzie Stevens
The relationship between George and Izzie Stevens lasted longer in nuance than it did in actuality. They had a powerful, supportive love, but it surely was extra of a finest pal who was at all times there for you.
First, George was in love with Izzie however saved quiet. Then when he was married, Izzie determined she cherished him too.
After a one-night stand, their relationship tried to take off. Most of us followers weren’t right here for it.
Thankfully, it faltered on the beginning line. They unanimously agreed it wasn’t the correct time. Unfortunately, they by no means noticed what might have been earlier than George died heroically.
Izzie Stevens and Denny Duquette
Despite the rule towards medical doctors courting their sufferers, Izzie Stevens fell for Denny Duquette, a affected person in want of a coronary heart transplant.
When it appeared like Denny would die earlier than getting a brand new organ, Izzie broke the legislation and her oath to push him up the transplant listing.
Although he obtained a brand new coronary heart and proposed to Izzie, he died of a stroke shortly after she accepted.
His dying continued to have an effect on Izzie by way of future ‘ships. His ghost recognized her mind tumor.
Callie Torres and Arizona Robbins
The relationship between Callie and Arizona was one among battle and drama and many on-again, off-again.
As Arizona courted Callie, she concurrently seduced the viewers.
The couple went by way of the ringer, experiencing job modifications, a disagreement on youngsters, and a airplane crash that killed a number of GSM medical doctors.
Fans knew we had been witnessing a love that would outlast something. Except we had been fallacious.
The couple had a number of main fights that ultimately led to a nasty custody battle over Sophia, the daughter Callie shared with Mark.
Most followers hated the best way their love story ended so brutally merciless. Callie left Grey Sloan to be along with her new girlfriend, Penny, in New York. Arizona adopted later to be near her daughter.
Fans discovered they reunited off-screen just a few years later. Arizona’s look on Grey’s Anatomy Season 20 Episode 4 left followers upset that we did not study the place the couple stands.
Callie Torez and Penny Blake
We weren’t positive what to make of Penny Blake when she joined Grey’s. And as soon as she turned the physician that killed Derek, we had our minds made up.
So, followers had combined emotions as soon as she and Callie obtained severe. While we wished our woman to be blissful, we weren’t positive it needs to be with Blake. The relationship did not keep on display so long as others but it surely had main impression.
When Blake obtained a job throughout the nation, Callie adopted. Unfortunately, not earlier than followers went by way of plenty of drama, just like the custody battle.
Grey’s followers ended up saying goodbye to a different of their favourite medical doctors. Later, it is talked about that the couple broke up just a few years after the transfer.
Alex Karev and Lexie Grey
Meredith is not the one Grey with relationship issues. Lexie additionally had fairly a time discovering real love.
Like a number of different Grey Sloan workers, she had a temporary fling with fellow physician Alex Karev. Fans noticed the writing on the wall from the beginning.
Poor Lexi can be doomed for heartache if she fell for Alex, since he was in love with another person. (See a pattern?)
Thankfully, she by no means totally invested within the relationship and wasn’t devastated when it fizzled out.
Alex Karev and Izzie Stevens
Izzie and Alex had been buddies earlier than they turned lovers. Given their horrible observe file for relationships — like falling for his or her sufferers — followers had combined emotions when the 2 began having chemistry.
Alone, each medical doctors had been a large number. But they introduced out the very best in one another.
The romance allowed the playboy Alex to redeem himself as he proposed to Izzie regardless of considering she was going to die from most cancers.
Instead of the marriage for Meredith and Derek, we watched Alex and Izzie take part holy matrimony.
Although Izzie survived her prognosis, their marriage didn’t. Fans had combined emotions about Alex’s determination to finish issues after Izzie left however returned for a second likelihood.
Alex Karev and Jo Wilson
Izzie had been good for Alex in some ways, together with serving to him mature into an amazing physician.
So when sparks flew between him and Jo Wilson, followers knew he was lastly prepared for a severe relationship.
Alex and Jo had been two peas in a pod regardless of all of the drama of their relationship stemming from the previous. When they lastly overcame their hurdles, we had been positive to see a fortunately ever after.
Things had been good till they weren’t. Without warning, Alex left at some point to go to his mother. Or so we thought.
Then abruptly, he is AWOL, no telephone calls, no correspondence. Complete ghosting.
Turned out he discovered his child mamma, Izzie, and selected to stick with her over his present spouse. Delivering the information and divorce papers within the mail? Harsh transfer, Doc!
Jo Wilson and Atticus Lincoln
After two failed marriages, Jo was hesitant to be with anybody else, particularly after adopting daughter Luna.
But who might resist falling for horny surgeon Link.
Link and Jo’s relationship goes again to their pre-doctor days, once they labored collectively as meals servers.
At first, they had been simply actually shut buddies, however followers noticed the chemistry.
The buddies turned lovers after Link’s failed relationship with Amelia gave him a son. While elevating their youngsters as single dad and mom, emotions grew right into a romantic love.
Season 20 has the 2 in couple mode, and issues appear to be going effectively to this point into the shortened season.
Jackson Avery and April Kepner
Jackson got here onto the scene because the boss’s son and April because the religious Christian.
After Jackson took April’s virginity, most followers anticipated them to remain collectively.
But after a lot pointless backwards and forwards, followers obtained over the redundancy and began to hope for one thing else.
We noticed plenty of repeated storylines — April virtually married the fallacious man, she left the nation, she got here again prepared to select up the place they left off.
Despite marriage and shared youngsters, Jackson was unwilling to place within the work, and their union fizzled out.
The couple divorced however later rekindled their ‘ship off-screen when April and their daughter adopted Jackson to Boston.
Jackson Avery and Lexie Grey
Grey’s Anatomy has been a revolving door of shared companions. Fans have seen loads of meant-to-be hookups and simply as many WTF are you considering ‘ships.
After Jackson and April break up up and Lexie dumped Mark, issues began to warmth up for the 2 newly single medical doctors.
The connection between Lexie and Jackson was primal and purely bodily, as each folks had been nonetheless in love with their “one.”
It was clear from the start that they had been utilizing one another as an escape.
So it did not shock anybody when Jackson dumped Lexie on account of nonetheless being in love with Mark.
Cristina Yang and Preston Burke
Cristina was everybody’s favourite good, egotistical surgeon, and Burke was the proper mentor. Their coupling break up followers.
The relationship appeared inappropriate for a lot of as a result of Burke was Cristina’s boss.
Although there have been challenges, such because the distinction in job title and non secular beliefs, the couple stayed collectively till their marriage ceremony day.
On what was to be the very best day of their lives, Cristina skilled the worst when Preston left her on their marriage ceremony day.
Cristina Yang and Owen Hunt
Owen Hunt got here to Grey Sloan in a flurry of motion and physician brilliance.
It’s no surprise his distinctive method of medical remedy caught the attention of Yang.
Their courtship was messy and appeared like it could finish a number of occasions, however they ended up married as an alternative.
Although there was a lot that ought to have saved them aside.
Several components labored, like nails in a coffin, to lastly finish their marriage. They initially divorced for the lawsuit after the airplane crash.
But Cristina left to take a job in Switzerland and totally ended their relationship when she realized Owen wished youngsters. She did not.
Amelia Shepherd and Owen Hunt
From our first introduction, Amelia was a large number. Although Derek’s sister, followers didn’t see a lot household resemblance.
Both medical doctors had a tough previous, with loads of demons nonetheless haunting them. Hunt had PTSD from his time at struggle.
Amelia was a drug addict with a mind tumor that brought about irrational conduct.
Misery loves firm, so nobody felt shocked when the couple tied the knot. Just as the wedding started, the couple argued about having youngsters, which led to an amicable divorce.
Fans watched in horror as they determined to strive their relationship once more after the mind tumor was gone.
But earlier than we needed to get on board with spherical 2, they skilled a last blowout that led to the tip of their coupling.
Amelia Shepherd and Atticus Link
After the failed ‘ship between Amelia and Owen, there was the potential of Amelia with Link.
Fans had been in love with the beautiful boy surgeon who gave Amelia all the eye and understanding she did not get with Owen.
He even pretended to be her former husband throughout a household dinner, so Amelia would not need to admit to her divorce.
He went to bat for her and followers weren’t the one ones to understand his help.
The couple began as buddies, grew into lovers, had a toddler collectively, and break up up. But regardless of their division, the couple are wonderful at co-parenting.
Owen Hunt and Teddy Altman
Teddy and Owen return pre-hospital to once they labored collectively abroad as Army surgeons.
Despite having emotions for one another within the desert, they begin with a platonic relationship as soon as Teddy involves Seattle Grace.
The couple lastly obtained their likelihood collectively after Owen went by way of a number of failed relationships, together with with Cristina and Amelia.
Things had been rocky from day 1 as Teddy struggled to be the backup. It wasn’t till she obtained pregnant that she was able to strive with Owen.
Who was nonetheless with Amelia.
After the start of their daughter, Owen lastly proposed to Teddy, who was in one other relationship on the similar time.
The couple are nonetheless married — though there’s typically drama — in Season 20.
Miranda Bailey and Ben Warren
Miranda’s huge persona and brilliance made everybody fall in love along with her, together with then-anesthesiologist Ben Warren — now a firefighter at Station 19.
After Bailey’s catastrophe of a wedding to her first husband Tuck, followers swooned over the extraordinary wooing Ben did to seize her consideration.
Everything in regards to the man appeared good, which solely appeared to work towards him as Bailey resisted his advances.
Fans are thrilled to see that her disinterest did not final lengthy.
Their love story is the epitome of what we predict an ideal marriage needs to be, even years later when most different relationships have fallen to the wayside.
Richard Webber and Catherine Fox
The early seasons of Grey’s Anatomy revealed the historical past between Richard and Meredith’s mom, efficiently laying the inspiration for the complete collection.
After the emotional ordeal of Richard’s first marriage, followers had been glad to see him get a second likelihood at love.
No one anticipated extra heartache within the works as his new love, Catherine, obtained sick too.
The man critically cannot catch a break! It’s no surprise he struggles with alcohol.
As of Season 20, followers are glad to see the wedding nonetheless going sturdy and maintain out hope that Catherine’s present well being prognosis continues to remain constructive.
Levi Schmitt and Nico Kim
Levi made fairly the impression as a surgical resident. Since his nerdy fumbling as a primary 12 months, he is turn out to be fairly the physician. Even if his love life hasn’t labored out as effectively.
Fans cheered in delight when Levi lastly discovered somebody to assist him discover his sexuality. Nico was the proper first, however followers by no means anticipated it to be Levi’s solely.
Unfortunately, their relationship did not final, however nobody ever forgets their first. Especially when it is as life-changing as realizing you are homosexual.
Many followers hoped that Nico would return and the couple might begin once more.
No one anticipated to see Nico re-appear in Season 20 Episode 3, fortunately married and with a child on the best way.
It broke poor Levi’s coronary heart, however followers hope it was the closure he wanted to lastly transfer on and discover his real love.
Maggie Pierce and Winston Ndugu
Maggie’s arrival at GSM brought about fairly a stir since Meredith was unaware she had one other sister.
And Richard was simply as shocked to search out out he had a daughter.
Maggie had just a few relationships earlier than Winston, together with Andrew DeLucas and a quick dalliance with Jackson Avery (whose mother was married to her dad).
At the start of their relationship, Maggie and Winston lived lengthy distance. She lived in Seattle, and he was in Boston.
After COVID, Winston relocated to Seattle to work at Grey Sloan, and the couple obtained engaged.
Things appeared to maneuver quick for them and the followers, leaving a lot to be desired. When the issues began, we barely had time to regulate to the wedding.
Sadly, followers stated goodbye to Maggie and the union in Season 19. The divorce papers delivered to Winston in Season 20 gave us a much-needed, if awkward, decision.
Simone Griffith and Lucas Adams
Simone and Lucas are two of the latest residents to hitch the ranks of Grey’s. Fans have paralleled their love story and that of Derek and Mer.
It’s no shock, given Lucas’s DNA. He is Derek’s nephew, in any case. He has greatness in his genes.
Lucas has been in love with Simone since they met.
And Simone was engaged to another person. The marriage ceremony virtually occurred, however Simone referred to as it off on the final minute.
No one, together with the couple, appears to know the place they stand. If issues can work out, we would have our subsequent real love story.
What do you consider this listing of the best relationships on Grey’s Anatomy? Is there a relationship we did not embody that you simply like?
Be positive to remark along with your choose for the very best couple.
Sara Trimble is a workers author for TV Fanatic. You can observe her on X.
